Development of olfactory projection neuron dendrites that contribute to wiring specificity of the Drosophila olfactory circuit

The antennal lobe (AL) of Drosophila is the first olfactory processing center in which olfactory input and output are spatially organized into distinct channels via glomeruli to form a discrete neural map. In each glomerulus, the axons of a single type of olfactory receptor neurons (ORNs) synapse wi...

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Bibliographic Details
Published in:Genes & Genetic Systems 2014, Vol.89(1), pp.17-26
Main Authors: Sakuma, Chisako, Anzo, Marie, Miura, Masayuki, Chihara, Takahiro
Format: Article
Language:English
Subjects:
Animals
dendrite
Dendrites - metabolism
Dendrites - physiology
development
Drosophila
Drosophila - growth & development
Drosophila - metabolism
Drosophila - physiology
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Neurogenesis
Olfactory Pathways - cytology
Olfactory Pathways - growth & development
Olfactory Pathways - metabolism
Olfactory Receptor Neurons - cytology
Olfactory Receptor Neurons - metabolism
olfactory system
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Summary:The antennal lobe (AL) of Drosophila is the first olfactory processing center in which olfactory input and output are spatially organized into distinct channels via glomeruli to form a discrete neural map. In each glomerulus, the axons of a single type of olfactory receptor neurons (ORNs) synapse with the dendrites of a single type of projection neurons (PNs). The AL is an ideal place to study how the wiring specificity between specific types of ORNs and PNs is established during development. During the past two decades, the involvement of diverse molecules in the specification and patterning of ORNs and PNs has been reported. Furthermore, local interneurons—another component of glomeruli—have been recently catalogued and their functions have been gradually dissected. Although there is accumulating knowledge about the involvement of these three cell types in the wiring specificity of the olfactory system, in this review, we focus especially on the development of PN dendrites.
ISSN:1341-7568
1880-5779
DOI:10.1266/ggs.89.17