Daptomycin is effective as antibiotic-lock therapy in a model of Staphylococcus aureus catheter-related infection

Summary Background The effectiveness of daptomycin versus vancomycin for treating experimental methicillin-susceptible (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) catheter-related infection by antibiotic-lock technique was assessed. Methods One MSSA strain and one clinical MRSA iso...

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Bibliographic Details
Published in:The Journal of infection 2014-06, Vol.68 (6), p.548-552
Main Authors: Meije, Yolanda, Almirante, Benito, Del Pozo, José Luis, Martín, María Teresa, Fernández-Hidalgo, Nuria, Shan, Adriana, Basas, Jana, Pahissa, Albert, Gavaldà, Joan
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Antibacterial agents
Antibiotic Prophylaxis - methods
Antibiotic-lock therapy
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Biofilms - drug effects
Biological and medical sciences
Catheter related bloodstream infection
Catheter-related infection
Catheter-Related Infections - prevention & control
Daptomycin
Daptomycin - administration & dosage
Disease Models, Animal
General aspects
Human bacterial diseases
Infectious Disease
Infectious diseases
Medical sciences
Pharmacology. Drug treatments
Rabbits
S. aureus biofilm
Staphylococcal Infections - prevention & control
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - physiology
Vancomycin
Vancomycin - administration & dosage
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Summary:Summary Background The effectiveness of daptomycin versus vancomycin for treating experimental methicillin-susceptible (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) catheter-related infection by antibiotic-lock technique was assessed. Methods One MSSA strain and one clinical MRSA isolate were used. A preliminary in vitro study determined the minimum biofilm eradication concentration (MBEC) of vancomycin and daptomycin. An intravenous catheter was implanted in New Zealand white rabbits. Infection was induced by 24 h locking the catheter with 0.3 mL of broth culture containing MSSA or MRSA. The 24 h of antibiotic-lock treatment groups were: control, vancomycin 10 mg/mL, daptomycin 5 mg/mL and daptomycin 50 mg/mL. Results Daptomycin showed greater in vitro activity than vancomycin against biofilm bacteria (MBECs of vancomycin and daptomycin for MSSA, >2000 mg/L and 7 mg/L; MRSA, >2000 mg/L and 15 mg/L). Daptomycin 5 mg/mL achieved significant reductions relative to vancomycin 10 mg/mL in log10  cfu recovered from catheter tips for both strains ( P  
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2014.01.001