Variability among brain regions in the specificity of 6-hydroxydopamine (6-OHDA)-induced lesions

6-Hydroxydopamine (6-OHDA) or vehicle was infused stereotaxically into the lateral ventricles of rats, usually following pretreatment with desmethylimipramine (DMI). Various brain regions were then assayed for dopamine (DA), serotonin (5-HT) and norepinephrine (NE). As expected, 6-OHDA depleted DA i...

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Bibliographic Details
Published in:Journal of Neural Transmission 1989-01, Vol.77 (2-3), p.197-210
Main Authors: COMMINS, D. L, SHAUGHNESSY, R. A, AXT, K. J, VOSMER, G, SEIDEN, L. S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Fundamental and applied biological sciences. Psychology
Vertebrates: nervous system and sense organs
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Summary:6-Hydroxydopamine (6-OHDA) or vehicle was infused stereotaxically into the lateral ventricles of rats, usually following pretreatment with desmethylimipramine (DMI). Various brain regions were then assayed for dopamine (DA), serotonin (5-HT) and norepinephrine (NE). As expected, 6-OHDA depleted DA in all brain regions examined. Unexpectedly, however, the two highest doses of 6-OHDA significantly decreased 5-HT levels in the hippocampus and increased 5-HT levels in the striatum. In addition, despite pretreatment with doses of DMI commonly considered adequate to block 6-OHDA-induced depletion of NE, all doses of 6-OHDA tested significantly reduced NE levels in the hippocampus, hypothalamus and septum.
ISSN:0300-9564
1435-1463
DOI:10.1007/BF01248932