Effect of NC-1100 (1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol dihydrochloride) on .GAMMA.-aminobutyric acid(GABA) metabolism in rat brain: Analysis using stroke-prone spontaneously hypertensive rat

Effects of oral administration of NC-1100 on the metabolism of neuroactive amino acids in rat brain were studied using stroke-prone spontaneously hypertensive (SHR-SP) and Wistar Kyoto rats. The repeated administration of NC-1100 induced a significant increase of gamma -aminobutyric acid (GABA) cont...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1989, Vol.50 (2), p.131-139
Main Authors: HASHIMOTO, Tsuneichi, KIMORI, Misa, NAKAMURA, Yoshiko, KURIYAMA, Kinya
Format: Article
Language:English
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Summary:Effects of oral administration of NC-1100 on the metabolism of neuroactive amino acids in rat brain were studied using stroke-prone spontaneously hypertensive (SHR-SP) and Wistar Kyoto rats. The repeated administration of NC-1100 induced a significant increase of gamma -aminobutyric acid (GABA) content in the cerebellum and medulla oblongata of SHR-SP. The decrease of aspartic acid contents in the cerebellum and medulla oblongata of SHR-SP was also noted following NC-1100 administration. The turnover rate of GABA was also significantly reduced in the cerebellum and medulla oblongata of SHR-SP. It was also found that the spontaneous release of preloaded ( super(3)H)GABA from cerebral cortical slices was significantly retarded by the continuous oral administration of NC-1100.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.50.131