Functional antagonism between nociceptin/orphanin FQ and corticotropin-releasing factor in rat anxiety-related behaviors: Involvement of the serotonergic system

Highlights • Nociceptin/orphanin FQ (N/OFQ) has been proposed as a functional antagonist of corticotropin-releasing factor (CRF). • Antagonism between N/OFQ and CRF in anxiety conditions and changes in the central 5-HTergic system were studied. • N/OFQ displayed anxiolytic-like effects and, administ...

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2014-08, Vol.48 (4), p.189-197
Main Authors: Filaferro, M, Ruggieri, V, Novi, C, Calò, G, Cifani, C, Micioni Di Bonaventura, M.V, Sandrini, M, Vitale, G
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Anxiety
Anxiety - psychology
Behavior, Animal - drug effects
Brain Chemistry - drug effects
Corticotropin-releasing factor (CRF)
Corticotropin-Releasing Hormone - antagonists & inhibitors
Corticotropin-Releasing Hormone - pharmacology
Endocrinology & Metabolism
Functional antagonism
Hydroxyindoleacetic Acid - metabolism
Male
Nociceptin
Nociceptin/orphanin FQ (N/OFQ)
Opioid Peptides - antagonists & inhibitors
Opioid Peptides - pharmacology
Rats
Rats, Wistar
Receptor, Serotonin, 5-HT1A - metabolism
Serotonergic system
Serotonin - physiology
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Summary:Highlights • Nociceptin/orphanin FQ (N/OFQ) has been proposed as a functional antagonist of corticotropin-releasing factor (CRF). • Antagonism between N/OFQ and CRF in anxiety conditions and changes in the central 5-HTergic system were studied. • N/OFQ displayed anxiolytic-like effects and, administered before CRF, counteracted anxiogenic-like effects evoked by CRF. • Either N/OFQ or CRF changed central 5-HTergic system parameters: their combination annulled the single drug’s effects. • The study shows that N/OFQ may be functional antagonist of CRF anxiogenic-like effects via central 5-HT system modulation.
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2014.05.001