Declining Prevalence of Coronary Artery Disease in Incident Dialysis Patients Over the Past Two Decades

• Published in: Journal of Atherosclerosis and Thrombosis 2014/06/25, Vol.21(6), pp.593-604
• Main Authors: Iwasaki, Masaki, Joki, Nobuhiko, Tanaka, Yuri, Hayashi, Toshihide, Kubo, Shun, Asakawa, Takasuke, Matsukane, Ai, Takahashi, Yasunori, Hirahata, Koichi, Imamura, Yoshihiko, Hase, Hiroki
• Format: Article
• Language: English
• Subjects: Aged; Body Mass Index; C-Reactive Protein - metabolism; Cardiovascular atherosclerosis; Cholesterol, HDL - blood; Chronic kidney disease; Coronary Artery Disease - complications; Coronary Artery Disease - epidemiology; Cross-Sectional Studies; Diabetic Nephropathies - complications; Erythropoietin-stimulating agents; Female; Humans; Incidence; Japan - epidemiology; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Logistic Models; Male; Middle Aged; Odds Ratio; Prevalence; Renal Dialysis; Renin angiotensin aldosterone system inhibitors; Statin
• ISSN: 1340-3478; 1880-3873
• DOI: 10.5551/jat.21337

Aim: The medical management of patients with chronic kidney disease(CKD) has changed within the past 20 years. We speculate that this change has resulted in a decrease in the prevalence of atherosclerotic cardiovascular disease in patients with CKD. The aim of the present study was to analyze changes in the prevalence of coronary artery disease(CAD) in patients newly started on hemodialysis, as well as trends in clinical factors and medications over the past two decades. Methods: This single-center cross-sectional study examined data for 315 consecutive patients starting hemodialysis(age, 64±12 years; men, 73%; diabetic nephropathy, 57%) between January 1993 and December 2010. All patients were routinely screened for CAD within three months of starting hemodialysis, regardless of whether ischemic heart disease was suspected. The patients were categorized into six groups based on the date of the initial dialysis session in order to compare the historical prevalence of unidentified CAD(uCAD) in association with the clinical factors. In addition, we performed a subgroup analysis among 222 patients without known cardiac disease. Results: The prevalence of uCAD gradually declined from 69% to 25% over 18 years(p＜0.001 for trend). The mean high-density lipoprotein cholesterol(HDL-C) concentration increased(p＜0.001 for trend), while the median C-reactive protein(CRP) level decreased over time. In parallel with these trends, the proportion of statin users significantly increased over time(p＜0.001 for trend). The use of erythropoiesis-stimulating agents(ESAs) and renin angiotensin aldosterone system inhibitors(RAS-Is) also increased during the same period(both p＜0.001 for trend). A univariate logistic regression analysis identified a significant association between the prevalence of uCAD and the use of ESAs(OR: 0.565, p=0.016) or RAS-Is(OR: 0.501, p=0.004). In addition, a lower BMI, lower HDL-Clevel and higher CRP level were found to be closely associated with uCAD, independent of confounding variables. The findings for the new dialysis patients without cardiac disease were similar. Conclusions: The prevalence of uCAD in patients with end-stage kidney disease has remarkably decreased over the past two decades. Major improvements in the medical management of CKD may modify the prevalence of coronary atherosclerosis.