A Method for Evaluation of Membrane Permeability for Water by the Erythrocyte Osmotic Deformability Profiles

We developed a method for evaluation of membrane permeability for water based on the analysis of osmotic permeability profiles of red blood cells. Deformability of completely spherulated erythrocytes changed in a dose-dependent manner during formation of artificial water pores (by nystatin) and bloc...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-05, Vol.157 (1), p.116-118
Main Author: Katyukhin, L. N.
Format: Article
Language:English
Subjects:
Biological Transport
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Membrane Permeability - drug effects
Cells, Cultured
Erythrocyte Deformability
Erythrocytes - cytology
Erythrocytes - drug effects
Erythrocytes - metabolism
Humans
Internal Medicine
Ionophores - pharmacology
Laboratory Medicine
Mercuric Chloride - pharmacology
Methods
Nystatin - pharmacology
Osmosis
Pathology
Permeability
Water
Water - metabolism
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Summary:We developed a method for evaluation of membrane permeability for water based on the analysis of osmotic permeability profiles of red blood cells. Deformability of completely spherulated erythrocytes changed in a dose-dependent manner during formation of artificial water pores (by nystatin) and blocking (by HgCl 2 ) of the existing ones.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2505-1