Comparison of the Efficiency of Transplantation of Bone Marrow Multipotent Mesenchymal Stromal Cells Cultured under Normoxic and Hypoxic Conditions and Their Conditioned Media on the Model of Acute Lung Injury

The therapeutic efficiency of intravenous injection of rat bone marrow multipotent mesenchymal stromal cells grown under conditions of normoxia and hypoxia (3% O 2 ) and conditioned media from these cultures were compared on the rat model of acute lung injury induced by intraperitoneal injection of...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-05, Vol.157 (1), p.138-142
Main Authors: Chailakhyan, R. K., Aver’yanov, A. V., Zabozlaev, F. G., Sobolev, P. A., Sorokina, A. V., Akul’shin, D. A., Gerasimov, Yu. V.
Format: Article
Language:English
Subjects:
Acute Lung Injury - chemically induced
Acute Lung Injury - metabolism
Acute Lung Injury - pathology
Acute Lung Injury - therapy
Acute respiratory distress syndrome
Animals
Antigens, CD - metabolism
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Bone marrow
Bone Marrow Cells - cytology
Bone Marrow Cells - drug effects
Bone Marrow Cells - metabolism
Cell Biology
Cell Hypoxia
Cells, Cultured
Comparative analysis
Culture Media, Conditioned - pharmacology
Health aspects
Hypoxia - metabolism
Hypoxia - pathology
Hypoxia - therapy
Injections, Intraperitoneal
Interleukin-1beta - biosynthesis
Interleukin-1beta - secretion
Interleukin-6 - biosynthesis
Interleukin-6 - secretion
Internal Medicine
Laboratory Medicine
Lipopolysaccharides
Male
Mesenchymal Stem Cell Transplantation
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - drug effects
Mesenchymal Stromal Cells - metabolism
Oxygen - pharmacology
Pathology
Rats
Rats, Wistar
Stem cells
Transplantation
Transplantation, Homologous
Treatment Outcome
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - secretion
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Description
Summary:The therapeutic efficiency of intravenous injection of rat bone marrow multipotent mesenchymal stromal cells grown under conditions of normoxia and hypoxia (3% O 2 ) and conditioned media from these cultures were compared on the rat model of acute lung injury induced by intraperitoneal injection of lipopolysaccharide. The best therapeutic efficiency was demonstrated by cells grown under hypoxic conditions. The effect of conditioned media was less pronounced and did not depend on the culturing conditions.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2509-x