Serum Hepcidin Levels Are Associated With Serum Triglycerides and Interleukin-6 Concentrations in Patients With End-Stage Renal Disease

Hepcidin has emerged as a peptide with a key role in the regulation of iron homeostasis in patients with chronic kidney disease (CKD), having a strong dependence on inflammation. Recent studies reveal that hepcidin may be also associated with the progression of atherosclerosis. This study was perfor...

Full description

Saved in:
Bibliographic Details
Published in:Therapeutic apheresis and dialysis 2014-06, Vol.18 (3), p.279-283
Main Authors: Samouilidou, Elisabeth, Pantelias, Konstantinos, Petras, Dimitrios, Tsirpanlis, George, Bakirtzi, Joulia, Chatzivasileiou, George, Tzanatos, Helen, Grapsa, Eirini
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Atherosclerosis
C-Reactive Protein - metabolism
Case-Control Studies
Hemodialysis
Hepcidin
Hepcidins - blood
Humans
Inflammation
Interleukin-6 - blood
Male
Middle Aged
Peritoneal dialysis
Peritoneal Dialysis - methods
Regression Analysis
Renal Dialysis - methods
Renal Insufficiency, Chronic - therapy
Triglycerides - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hepcidin has emerged as a peptide with a key role in the regulation of iron homeostasis in patients with chronic kidney disease (CKD), having a strong dependence on inflammation. Recent studies reveal that hepcidin may be also associated with the progression of atherosclerosis. This study was performed to analyze the relation of hepcidin to markers of atherosclerosis and inflammation in patients on dialysis. A total of 90 individuals were enrolled. Sixty patients with end‐stage renal disease, who were on hemodialysis (HD) (N = 30) and peritoneal dialysis (N = 30) were compared with 30 normal controls (NC). Age, body mass index, time on dialysis, serum lipids, C‐reactive protein (CRP) and interleukin‐6 (IL‐6) were measured and analyzed in correlation with hepcidin concentration. It was found that patients on HD and peritoneal dialysis have significantly higher (P 
ISSN:1744-9979
1744-9987
DOI:10.1111/1744-9987.12102