Regeneration effect of visible light-curing furfuryl alginate compound by release of epidermal growth factor for wound healing application

ABSTRACT A visible light‐curable polysaccharide conjugate was prepared and was included with epidermal growth factor (EGF) for wound healing application. Alginate was modified with furfurylamine, and the furfuryl alginate (F‐alginate) was mixed with Rose Bengal for visible light reactivity. The intr...

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Bibliographic Details
Published in:Journal of applied polymer science 2014-07, Vol.131 (14), p.np-n/a
Main Authors: Heo, Yun, Lee, Hyung-Jae, Kim, Eun-Hye, Kim, Mi-Kyung, Ito, Yoshihiro, Son, Tae-Il
Format: Article
Language:English
Subjects:
Alginates
Antiinfectives and antibacterials
Applied sciences
bioengineering
Biological and medical sciences
biomaterials
biomedical applications
Conjugates
Exact sciences and technology
Growth factors
Materials science
Medical sciences
Micropatterning
Natural polymers
photochemistry
Physicochemistry of polymers
Polymers
polysaccharides
Spectroscopy
Starch and polysaccharides
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Weight measurement
Wound healing
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Summary:ABSTRACT A visible light‐curable polysaccharide conjugate was prepared and was included with epidermal growth factor (EGF) for wound healing application. Alginate was modified with furfurylamine, and the furfuryl alginate (F‐alginate) was mixed with Rose Bengal for visible light reactivity. The introduction of furfuryl group was confirmed by 1H‐NMR and UV/vis spectroscopy. Visible light‐induced crosslinking was evaluated by micropatterning and weight measurement. Swelling ratio was also determined. To verify its applicability in wound healing applications, EGF was included in the system of F‐alginate and Rose Bengal. After the confirmation of no cytotoxicity of F‐alginate and murine EGF release from the system, cell proliferation, antibacterial activity, and animal test were performed on the system. In conclusion, it was demonstrated that the system was useful for wound healing. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40113.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.40113