Pro-inflammatory cytokine associated with somatic and pain symptoms in depression

Abstract Background More than two-thirds of depressed patients complain of somatic and pain symptoms, which are frequently regarded as a psychological reaction. Although there is a growing body of evidence showing that depression is related to immune abnormalities, few studies have investigated the...

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Bibliographic Details
Published in:Journal of affective disorders 2014-02, Vol.155, p.28-34
Main Authors: Bai, Ya-Mei, Chiou, Wen-Fei, Su, Tung-Ping, Li, Cheng-Ta, Chen, Mu-Hong
Format: Article
Language:English
Subjects:
Adiponectin - adverse effects
Adiponectin - analysis
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Body Mass Index
C-Reactive Protein - adverse effects
C-Reactive Protein - analysis
Case-Control Studies
Chemokine CCL2 - adverse effects
Chemokine CCL2 - analysis
Cytokines - adverse effects
Cytokines - analysis
Depression
Depression - blood
Depression - epidemiology
Depression - immunology
Depressive personality disorders
Enzyme-Linked Immunosorbent Assay
Female
Gender
Humans
Male
Medical sciences
Middle Aged
Miscellaneous
Mood disorders
P-Selectin - adverse effects
P-Selectin - analysis
Pain
Pain - blood
Pain - epidemiology
Pain - immunology
Pro-inflammatory cytokines
Psychiatric Status Rating Scales
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Interleukin-2 - analysis
Receptors, Interleukin-6 - analysis
Receptors, Tumor Necrosis Factor - analysis
Severity of Illness Index
Somatic and pain symptoms
Somatic symptoms
Somatoform Disorders - blood
Somatoform Disorders - epidemiology
Somatoform Disorders - immunology
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Summary:Abstract Background More than two-thirds of depressed patients complain of somatic and pain symptoms, which are frequently regarded as a psychological reaction. Although there is a growing body of evidence showing that depression is related to immune abnormalities, few studies have investigated the association between inflammatory cytokines and somatic/pain symptoms. Method Patients with depressive disorder but without any medical disorders, and age/gender/body mass index (BMI)-matched healthy subjects were enrolled. All the subjects completed the self-rating scales of the Beck Depression Inventory-II and the Depression and Somatic Symptoms Scale, which was comprised of depressive, somatic, and pain subscales. Pro-inflammatory cytokines, including C-reactive protein (CRP), interleukin-2 receptor (sIL-2R), soluble interleukin 6 receptor (sIL-6R), soluble TNF-receptors (sTNF-R), soluble P-selectin (sP-selectin), monocyte chemotactic protein-1 (MCP-1), and adiponectin, were assessed by enzyme-linked immunosorbent assays. Results In all, 109 patients with depressive disorder and 126 normal controls were enrolled. The patients with depressive disorder had significantly more severe depression, somatic and pain symptoms (all p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2013.10.019