Association between OPCRIT dimensions and polymorphisms of HPA axis genes in bipolar disorder

Abstract The aim of the study was to investigate the possible association between polymorphisms of HPA axis genes- CRHR1 (corticotrophin-releasing hormone receptor), NR3C1 (glucocorticoid receptor) and AVPR1B (arginine vasopressin receptor) and dimensions of bipolar disorder assessed by OPCRIT. We e...

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Bibliographic Details
Published in:Journal of affective disorders 2013-11, Vol.151 (2), p.744-747
Main Authors: Leszczyńska-Rodziewicz, Anna, Maciukiewicz, Małgorzata, Szczepankiewicz, Aleksandra, Pogłodziński, Andrzej, Hauser, Joanna
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affective disorders
Biological and medical sciences
Bipolar affective disorder
Bipolar disorder
Bipolar Disorder - genetics
Bipolar disorders
Diagnosis
Female
Genes
HPA axis
Humans
Male
Medical sciences
Middle Aged
Miscellaneous
Mood disorders
OPCRIT dimension
Polymorphism, Genetic
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Receptors, Corticotropin-Releasing Hormone - genetics
Receptors, Glucocorticoid - genetics
Receptors, Vasopressin - genetics
Vasopressin
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Summary:Abstract The aim of the study was to investigate the possible association between polymorphisms of HPA axis genes- CRHR1 (corticotrophin-releasing hormone receptor), NR3C1 (glucocorticoid receptor) and AVPR1B (arginine vasopressin receptor) and dimensions of bipolar disorder assessed by OPCRIT. We examined 560 patients with diagnosis of bipolar disorder ( n =457) and unipolar disorder ( n =103). Diagnosis was established by SCID and OPCRIT. We found association between polymorphisms of AVPR1b gene and psychotic dimension and CRHR1 polymorphisms and excitement and psychotic dimension. Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2013.08.012