Risk factors associated with the diagnosis of chronic Chagasic miocardiopathy in seropositive individuals from Barinas state, Venezuela

This study evaluates the risk factors associated with the diagnosis of chronic chagasic miocardiopathy (CChM) in 115 seropositive individuals to anti-Trypanosoma cruzi antibodies, in Barinas state, Venezuela. Serology was performed with ELISA and MABA; while the CChM diagnosis was established by ele...

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Bibliographic Details
Published in:Investigación clínica 2014-06, Vol.55 (2), p.119-132
Main Authors: González, Beatriz, Silva, Martha, Al-Atrache, Yusra, Delgado, Yelitze, Serrano, José Luis, Doccimo, Angelina, Hernández, Huber, Verde, Juan, Morillo, Daniela, Marín, Jaime, Concepción, Juan Luis, Bonfante-Cabarcas, Rafael, Rodríguez-Bonfante, Claudina
Format: Article
Language:Spanish
Subjects:
Animals
Animals, Wild - parasitology
Antibodies, Protozoan - blood
Chagas Cardiomyopathy - diagnosis
Chagas Cardiomyopathy - epidemiology
Comorbidity
Diet
Disease Reservoirs - parasitology
Emotions
Female
Gastrointestinal Diseases - epidemiology
Habits
Heart Failure - etiology
Housing
Humans
Hypertension - epidemiology
Immunoglobulin G - blood
Male
Middle Aged
Physical Examination
Risk Factors
Severity of Illness Index
Tobacco, Smokeless
Trypanosoma cruzi - immunology
Venezuela - epidemiology
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Summary:This study evaluates the risk factors associated with the diagnosis of chronic chagasic miocardiopathy (CChM) in 115 seropositive individuals to anti-Trypanosoma cruzi antibodies, in Barinas state, Venezuela. Serology was performed with ELISA and MABA; while the CChM diagnosis was established by electrocardiography and echocardiography. A complete clinical history including epidemiological, personal/familiar antecedents and psychobiological habits, plus socioeconomic, psychosocial and alimentary habits interviews were performed for each individual. Risk factors were determined through binary logistic regression. Results showed that 81 patients (70,4%; CI 95% = 66.4-74.4) had criteria for CChM, of which 74 (64.4%; IC 95% = 60.2-68.6) were in phase II; while 34 (29.6%; IC 95% = 25.5-33.5) were in phase I of the disease and 7 (6.1%; IC 95% = 4.0-8.2) in phase III. In a one year period, two patients in phase III died of heart failure. The diagnosis of CChM was associated with hunting practice, maternal history of cardiopathies, chewing chimó, medical history of hypertension and apex beat visible; it was negatively associated with canned and preserved foods ingest. In conclusion the CChM diagnosis has high frequency in seropositive individuals in Barinas and heart failure prevention must be based on an early medical attention and educative strategies in order to control risk factors.
ISSN:0535-5133