Chitosan and the mucosal delivery of biotechnology drugs

Recent human and animal studies have indicated that chitosan-based delivery systems are promising alternatives to conventional formulation approaches for the mucosal delivery of biotechnology drugs, such as proteins and genes. Here, we briefly analyze the current chitosan literature, review promisin...

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Bibliographic Details
Published in:Drug discovery today. Technologies 2005, Vol.2 (1), p.1-6
Main Authors: Issa, Mohamed M., Köping-Höggård, Magnus, Artursson, Per
Format: Article
Language:English
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Summary:Recent human and animal studies have indicated that chitosan-based delivery systems are promising alternatives to conventional formulation approaches for the mucosal delivery of biotechnology drugs, such as proteins and genes. Here, we briefly analyze the current chitosan literature, review promising in vivo studies, discuss the inherent biological properties of chitosan and present new selected technological advances using chitosan delivery systems. Daan J.A. Crommelin – Department of Pharmaceutical Sciences, Utrecht University, Utrecht, NL Gerrit Borchard – Enzon Pharmaceuticals, Piscataway, NJ, USA
ISSN:1740-6749
1740-6749
DOI:10.1016/j.ddtec.2005.05.008