A Universal Method for Measuring Functional Activity of Complement in Humans, Laboratory, Domestic, and Agricultural Animals, Amphibians, and Birds

A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the h...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-06, Vol.157 (2), p.285-287
Main Authors: Kuleshina, O. N., Kozlov, L. V., Cheremnykh, E. G.
Format: Article
Language:English
Subjects:
Amphibians
Animals
Biomedical and Life Sciences
Biomedicine
Birds
Cell Biology
Complement System Proteins - metabolism
Humans
Internal Medicine
Laboratory Medicine
Pathology
Tetrahymena pyriformis - metabolism
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Summary:A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, measured activity of the complement shows no erroneously high results caused by reactive lysis in febrile patients. The method can be used for studies of the complement system in humans and animals without species-specifi c adaptation.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2546-5