Kinetic modelling of coupled transport across biological membranes

In this report, we have modelled a secondary active co-transporter (symport and antiport), based on the classical kinetics model. Michaelis-Menten model of enzyme kinetics for a single substrate, single intermediate enzyme catalyzed reaction was proposed more than a hundred years ago. However, no si...

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Bibliographic Details
Published in:Indian journal of biochemistry & biophysics 2014-04, Vol.51 (2), p.93-99
Main Authors: Korla, Kalyani, Mitra, Chanchal K
Format: Article
Language:English
Subjects:
Biological Transport
Cell Membrane - metabolism
Enzymes - metabolism
Humans
Ion Transport
Kinetics
Mathematics
Models, Theoretical
Online Access:Get full text
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Summary:In this report, we have modelled a secondary active co-transporter (symport and antiport), based on the classical kinetics model. Michaelis-Menten model of enzyme kinetics for a single substrate, single intermediate enzyme catalyzed reaction was proposed more than a hundred years ago. However, no single model for the kinetics of co-transport of molecules across a membrane is available in the literature We have made several simplifying assumptions and have followed the basic Michaelis-Menten approach. The results have been simulated using GNU Octave. The results will be useful in general kinetic simulations and modelling.
ISSN:0301-1208