Metastatic spinal cord compression from pancreatic cancer

Pancreatic cancer is an extremely rare entity in patients with metastatic epidural spinal cord compression (MESCC). This study aimed to identify prognostic factors for functional outcome and survival following irradiation. Ten variables were investigated in 15 patients: age, gender, performance scor...

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Bibliographic Details
Published in:Anticancer research 2014-07, Vol.34 (7), p.3727-3730
Main Authors: Rades, Dirk, Huttenlocher, Stefan, Schild, Steven E, Bartscht, Tobias
Format: Article
Language:English
Subjects:
Bone Neoplasms - radiotherapy
Bone Neoplasms - secondary
Cohort Studies
Humans
Kaplan-Meier Estimate
Middle Aged
Motor Activity - physiology
Neoplasm Metastasis
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - physiopathology
Pancreatic Neoplasms - radiotherapy
Prognosis
Spinal Cord Compression - pathology
Spinal Cord Compression - physiopathology
Spinal Cord Compression - radiotherapy
Treatment Outcome
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Summary:Pancreatic cancer is an extremely rare entity in patients with metastatic epidural spinal cord compression (MESCC). This study aimed to identify prognostic factors for functional outcome and survival following irradiation. Ten variables were investigated in 15 patients: age, gender, performance score, time from diagnosis of pancreatic cancer to MESCC, number of involved vertebrae, ambulatory status, bone metastases, organ metastases, time developing motor deficits, and the radiation schedule (1×8 Gy vs. fractionated radiotherapy schedules). Better post-treatment motor function was significantly associated with absence of organ metastases (p=0.025). Better survival was also significantly associated with absence of organ metastases: 6-month survival rates were 100% and 9%, respectively (p=0.006). The radiation schedule had no significant impact on treatment outcomes. Patients with organ metastases have a very limited life expectancy and are good candidates for irradiation with 1×8 Gy instead of fractionated schedules.
ISSN:1791-7530