Activity of the Glutathione Antioxidant System and NADPH-Generating Enzymes in Blood Serum of Rats with Type 2 Diabetes Mellitus after Administration of Melatonin-Correcting Drugs

We studied the effects of epifamin and melaxen on serum content of reduced glutathione and activities of glutathione peroxidase, glutathione reductase, and NADPH-generating enzymes (glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase) in rats with type 2 diabetes mellitus. The concen...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-06, Vol.157 (2), p.198-201
Main Authors: Agarkov, A. A., Popova, T. N., Verevkin, A. N., Matasova, L. V.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Biological products
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dextrose
Diabetes Mellitus, Type 2 - blood
Diabetes therapy
Enzyme Activation - drug effects
Glucose
Glucose metabolism
Glucosephosphate Dehydrogenase - blood
Glutathione - blood
Glutathione Peroxidase - blood
Glutathione Reductase - blood
Internal Medicine
Laboratory Medicine
Male
Melatonin
Pathology
Peptides - pharmacology
Phosphates
Rats
Type 2 diabetes
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Summary:We studied the effects of epifamin and melaxen on serum content of reduced glutathione and activities of glutathione peroxidase, glutathione reductase, and NADPH-generating enzymes (glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase) in rats with type 2 diabetes mellitus. The concentration of reduced glutathione was decreased in rats with this disease (by 1.8 times), but increased after treatment with epifamin and melaxen (by 1.6 and 1.7 times, respectively). Activities of glutathione peroxidase, glutathione reductase, and NADPHgenerating enzymes returned to the control level. Correction of melatonin concentration after treatment with the test drugs was probably followed by inhibition of free radical processes. The observed changes were accompanied by normalization of activity of the glutathione antioxidant system and NADPH-generating enzymes required for normal function of this system.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2524-y