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Lack of Influence of Dyspareunia on the Beneficial Effect of Intravaginal Prasterone (Dehydroepiandrosterone, DHEA) on Sexual Dysfunction in Postmenopausal Women

We have previously observed that intravaginal prasterone (dehydroepiandrosterone, DHEA) improved all domains of female sexual dysfunction (FSD). Investigate the influence of moderate/severe pain at sexual activity (dyspareunia) (MSD) at baseline on FSD following prasterone administration. The effect...

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Published in:Journal of sexual medicine 2014-07, Vol.11 (7), p.1766-1785
Main Authors: Labrie, Fernand, Archer, David, Bouchard, Céline, Fortier, Michel, Cusan, Leonello, Gomez, José‐Luis, Girard, Ginette, Baron, Mira, Ayotte, Normand, Moreau, Michèle, Dubé, Robert, Côté, Isabelle, Labrie, Claude, Lavoie, Lyne, Gilbert, Lucy, Martel, Céline, Balser, John
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Language:English
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Summary:We have previously observed that intravaginal prasterone (dehydroepiandrosterone, DHEA) improved all domains of female sexual dysfunction (FSD). Investigate the influence of moderate/severe pain at sexual activity (dyspareunia) (MSD) at baseline on FSD following prasterone administration. The effect of daily administration of prasterone (0, 3.25 mg, 6.5 mg or 13 mg) for 12 weeks on FSD in 215 postmenopausal women with or without MSD at baseline was evaluated in a prospective, randomized, double‐blind, and placebo‐controlled phase III clinical trial. Differences were examined on desire, arousal and orgasm. Comparable benefits were observed in women not having MSD (n = 56) vs. those having MSD (n = 159). The benefits over placebo in prasterone‐treated women for desire, avoiding intimacy and vaginal dryness as well as for the total sexual domain of the MENQOL (Menopause Specific Quality of Life) questionnaire, ranged between 18.0% and 38.2% with P values of
ISSN:1743-6095
1743-6109
DOI:10.1111/jsm.12517