Norsampsones A–D, Four New Decarbonyl Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii

Norsampsones A–D (1–4), four new decarbonyl polycyclic polyprenylated acylphloroglucinols, together with a new biogenetically related compound hypersampsone M (5), were isolated from the aerial parts of Hypericum sampsonii. Norsampsones A–D featured an unprecedented carbon skeleton with the loss of...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2014-07, Vol.16 (13), p.3448-3451
Main Authors: Tian, Wen-Jing, Yu, Yang, Yao, Xiao-Jun, Chen, Hai-Feng, Dai, Yi, Zhang, Xiao-Kun, Yao, Xin-Sheng
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Hypericum - chemistry
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Polycyclic Aromatic Hydrocarbons - chemistry
Polycyclic Aromatic Hydrocarbons - isolation & purification
Polycyclic Aromatic Hydrocarbons - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Norsampsones A–D (1–4), four new decarbonyl polycyclic polyprenylated acylphloroglucinols, together with a new biogenetically related compound hypersampsone M (5), were isolated from the aerial parts of Hypericum sampsonii. Norsampsones A–D featured an unprecedented carbon skeleton with the loss of C-2 carbonyl in the phloroglucinol ring. All structures were determined by extensive NMR spectroscopic methods, ECD calculation, and single-crystal X-ray diffraction.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol501333k