HKOCl‑2 Series of Green BODIPY-Based Fluorescent Probes for Hypochlorous Acid Detection and Imaging in Live Cells

A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macropha...

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Bibliographic Details
Published in:Organic letters 2014-07, Vol.16 (13), p.3544-3547
Main Authors: Hu, Jun Jacob, Wong, Nai-Kei, Gu, Qiangshuai, Bai, Xiaoyu, Ye, Sen, Yang, Dan
Format: Article
Language:English
Subjects:
Animals
Boron Compounds - chemistry
Diagnostic Imaging
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Humans
Hypochlorous Acid - analysis
Hypochlorous Acid - chemistry
Macrophages - metabolism
Mice
Molecular Structure
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Summary:A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol501496n