Inflammatory cytokine concentrations in uterine flush and serum samples from dairy cows with clinical or subclinical endometritis

The objective of this study was to compare the concentrations of inflammatory cytokines in uterine flush and serum from healthy postpartum dairy cows and cows with clinical or subclinical endometritis. Clinical endometritis was diagnosed by observation of vaginal discharges (>50% pus) and subclin...

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Bibliographic Details
Published in:Theriogenology 2014-08, Vol.82 (3), p.427-432
Main Authors: Kim, Ill-Hwa, Kang, Hyun-Gu, Jeong, Jae-Kwan, Hur, Tai-Young, Jung, Young-Hun
Format: Article
Language:English
Subjects:
Animals
Cattle
Cattle Diseases - blood
Cattle Diseases - immunology
Cytokines
Cytokines - blood
Cytokines - metabolism
Dairy cows
Endometritis
Endometritis - blood
Endometritis - immunology
Endometritis - veterinary
Female
Postpartum Period
Serum
Uterine flush
Uterus - immunology
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Summary:The objective of this study was to compare the concentrations of inflammatory cytokines in uterine flush and serum from healthy postpartum dairy cows and cows with clinical or subclinical endometritis. Clinical endometritis was diagnosed by observation of vaginal discharges (>50% pus) and subclinical endometritis was diagnosed by evaluation of uterine cytology (neutrophils >18%) at 4 weeks postpartum. Uterine flush was obtained from 48 cows at 4, 6, and 8 weeks postpartum for evaluation of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, and IL-10 concentrations. Serum samples were obtained from 34 cows just after calving and at 1, 2, 4, 6, and 8 weeks postpartum for evaluation of TNF-α, IL-1β, and IL-6 concentrations. Concentrations of TNF-α, IL-6, and IL-10 were greater (P 
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2014.04.022