Physiological Functions and Underlying Mechanisms of Fibroblast Growth Factor (FGF) Family Members: Recent Findings and Implications for Their Pharmacological Application

Despite their name, fibroblast growth factors (FGFs) are multifunctional regulators affecting a wide variety of physiological events. This review summarizes our recent studies on FGFs from mechanistic, physiological and application-oriented viewpoints. These include studies on the importance of βKlo...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2014/07/01, Vol.37(7), pp.1081-1089
Main Author: Imamura, Toru
Format: Article
Language:English
Subjects:
Animals
Cell Line
co-receptor
fibroblast growth factor (FGF)
Fibroblast Growth Factors - genetics
Fibroblast Growth Factors - pharmacology
Fibroblast Growth Factors - physiology
glycosaminoglycan
Hair Follicle - growth & development
Hair Follicle - metabolism
hair growth cycle
Humans
Membrane Proteins - genetics
Membrane Proteins - metabolism
Radiation Injuries, Experimental - prevention & control
Radiation-Protective Agents - pharmacology
radioprotection
Receptors, Fibroblast Growth Factor - genetics
Receptors, Fibroblast Growth Factor - metabolism
Recombinant Fusion Proteins - pharmacology
Signal Transduction
stem cell
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Summary:Despite their name, fibroblast growth factors (FGFs) are multifunctional regulators affecting a wide variety of physiological events. This review summarizes our recent studies on FGFs from mechanistic, physiological and application-oriented viewpoints. These include studies on the importance of βKlotho and glycosaminoglycans for the signaling of hormonal FGFs (FGF21 and FGF19); the physiological role of a paracrine FGF (FGF18) in hair cycle regulation; and the development of a stable, chimeric FGF protein composed of FGF1 and FGF2 domains suitable for radioprotection.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b14-00265