Periconceptional undernutrition in sheep leads to decreased locomotor activity in a natural environment

Maternal undernutrition during pregnancy increases offspring obesity and metabolic disease risk. We hypothesized that periconceptional undernutrition in sheep from 60 days before conception through to day 30 of gestation (UN) would decrease voluntary locomotor activity in adult offspring. Distance t...

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Bibliographic Details
Published in:Journal of developmental origins of health and disease 2013-08, Vol.4 (4), p.296-299
Main Authors: Donovan, E. L., Hernandez, C. E., Matthews, L. R., Oliver, M. H., Jaquiery, A. L., Bloomfield, F. H., Harding, J. E.
Format: Article
Language:English
Subjects:
Animals
Appetite
Brief Report
Cardiovascular disease
Diabetes
Endocrinology
Epigenetics
Exercise
Females
Males
Metabolism
Nutrition
Obesity
Premature birth
Sheep
Weight control
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Summary:Maternal undernutrition during pregnancy increases offspring obesity and metabolic disease risk. We hypothesized that periconceptional undernutrition in sheep from 60 days before conception through to day 30 of gestation (UN) would decrease voluntary locomotor activity in adult offspring. Distance travelled was measured at 18 months of age for ∼48 h in the paddock. Data were analysed using multiple regression analysis, with explanatory variables including sex, nutrition group, birth weight, average time between GPS measurements and percentage of time during the measurement period spent in daylight. Mean (±s.e.) distance walked (m/h) was greater for control (CON) than UN animals, and greater for females than males [110.2 (6.5), CON females; 110.7 (6.3), CON males; 105.1 (5.3), UN females and 95.5 (5.8), UN males; P = 0.02 for nutrition group effect and for sex effect]. Periconceptional undernutrition may lead to a significant decrease in voluntary physical activity in adult offspring.
ISSN:2040-1744
2040-1752
DOI:10.1017/S2040174413000214