Toxic 12,13-epoxytrichothecenes from anise fruits infected with Trichothecium roseum

Four 12,13-epoxytrichothecenes, viz., 4-O-acetyltrichothecolone (1), 4-O-cinnamoyltrichothecolone (2), trichothecoline (3), and trichothecin (4), were isolated and characterized from anise fruits infected in fields with Trichothecium roseum van Beyma (CMI-IMI 225229). Among these compounds, 1 and 2...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1982-01, Vol.30 (1), p.106-109
Main Authors: Ghosal, Shibnath, Chakrabarti, Dilip K, Srivastava, Arun K, Srivastava, Radhey S
Format: Article
Language:English
Subjects:
Pimpinella anisum
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Summary:Four 12,13-epoxytrichothecenes, viz., 4-O-acetyltrichothecolone (1), 4-O-cinnamoyltrichothecolone (2), trichothecoline (3), and trichothecin (4), were isolated and characterized from anise fruits infected in fields with Trichothecium roseum van Beyma (CMI-IMI 225229). Among these compounds, 1 and 2 are naturally occurring new 12,13-epoxytrichothecenes. From the in vitro culture extracts of the fungus, only 1, 3, and 4 were isolated and identified. Thus, the host-parasite interaction was suggested for the formation of 2, its cinnamoyl moiety being a metabolite of the host species. The total chloroform extractives of the moldy anise fruits produced dermatitic skin reactions in albino rats on external application and caused listlessness, anorexia, diarrhea, and stunted growth when ingested. The circumstantial evidence suggests toxin risk in man from prolonged ingestion of moldy anise fruits.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf00109a024