Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms

Highlights • Protection against oxidative stress provides microbial biofilms with tolerance to cidal drugs. • In bacteria, the antibiotic-induced expression of efflux systems is linked to biofilm resistance. • The biofilm matrix and cell envelope-associated polysaccharides contribute to tolerance. •...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2014-06, Vol.22 (6), p.326-333
Main Authors: Van Acker, Heleen, Van Dijck, Patrick, Coenye, Tom
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
antibiotics
Bacteria - drug effects
Bacterial Physiological Phenomena
biofilm
biofilm matrix
Biofilms - drug effects
Drug Resistance, Bacterial
Drug Resistance, Fungal
efflux
Fungi - drug effects
Fungi - physiology
Internal Medicine
Microbial Sensitivity Tests
Models, Biological
Oxidative Stress - drug effects
persisters
Reactive Oxygen Species - metabolism
resistance
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Summary:Highlights • Protection against oxidative stress provides microbial biofilms with tolerance to cidal drugs. • In bacteria, the antibiotic-induced expression of efflux systems is linked to biofilm resistance. • The biofilm matrix and cell envelope-associated polysaccharides contribute to tolerance. • There is evidence that suggests these mechanisms are not independent.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2014.02.001