The immunomodulating role of exercise in metabolic disease

Highlights • Lipid accumulation is linked to inflammation in a setting of nutrient overload. • Exercise training reduces levels of proinflammatory cytokines in adipose tissue. • Exercise may reduce inflammation by decreasing lipid accretion in liver and muscle. • Anti-inflammatory effects may be med...

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Bibliographic Details
Published in:Trends in immunology 2014-06, Vol.35 (6), p.262-269
Main Authors: Lancaster, Graeme I, Febbraio, Mark A
Format: Article
Language:English
Subjects:
Adipose Tissue - immunology
Adipose Tissue - metabolism
Allergy and Immunology
Animals
anti-inflammatory
Exercise
Humans
immune cells
Immune system
Immunity
Immunomodulation
inflammation
Inflammation - immunology
Inflammation - metabolism
Insulin
Insulin resistance
Interleukin-1 - metabolism
Lipid Metabolism
Liver - immunology
Liver - metabolism
metabolic disease
Metabolic Diseases - immunology
Metabolic Diseases - metabolism
Metabolic disorders
muscle
Muscle, Skeletal - immunology
Muscle, Skeletal - metabolism
Obesity
Obesity - immunology
Obesity - metabolism
Rodents
Signal Transduction
Toll-Like Receptors - metabolism
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Summary:Highlights • Lipid accumulation is linked to inflammation in a setting of nutrient overload. • Exercise training reduces levels of proinflammatory cytokines in adipose tissue. • Exercise may reduce inflammation by decreasing lipid accretion in liver and muscle. • Anti-inflammatory effects may be mediated via inhibition of TLR and IL-1 signaling.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2014.02.008