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The immunomodulating role of exercise in metabolic disease
Highlights • Lipid accumulation is linked to inflammation in a setting of nutrient overload. • Exercise training reduces levels of proinflammatory cytokines in adipose tissue. • Exercise may reduce inflammation by decreasing lipid accretion in liver and muscle. • Anti-inflammatory effects may be med...
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| Published in: | Trends in immunology 2014-06, Vol.35 (6), p.262-269 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c433t-d55e01461b9483eb00f9a621318cff1315f32febc49c3f9535f308bd7ca061983 |
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| cites | cdi_FETCH-LOGICAL-c433t-d55e01461b9483eb00f9a621318cff1315f32febc49c3f9535f308bd7ca061983 |
| container_end_page | 269 |
| container_issue | 6 |
| container_start_page | 262 |
| container_title | Trends in immunology |
| container_volume | 35 |
| creator | Lancaster, Graeme I Febbraio, Mark A |
| description | Highlights • Lipid accumulation is linked to inflammation in a setting of nutrient overload. • Exercise training reduces levels of proinflammatory cytokines in adipose tissue. • Exercise may reduce inflammation by decreasing lipid accretion in liver and muscle. • Anti-inflammatory effects may be mediated via inhibition of TLR and IL-1 signaling. |
| doi_str_mv | 10.1016/j.it.2014.02.008 |
| format | article |
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| ispartof | Trends in immunology, 2014-06, Vol.35 (6), p.262-269 |
| issn | 1471-4906 1471-4981 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Adipose Tissue - immunology Adipose Tissue - metabolism Allergy and Immunology Animals anti-inflammatory Exercise Humans immune cells Immune system Immunity Immunomodulation inflammation Inflammation - immunology Inflammation - metabolism Insulin Insulin resistance Interleukin-1 - metabolism Lipid Metabolism Liver - immunology Liver - metabolism metabolic disease Metabolic Diseases - immunology Metabolic Diseases - metabolism Metabolic disorders muscle Muscle, Skeletal - immunology Muscle, Skeletal - metabolism Obesity Obesity - immunology Obesity - metabolism Rodents Signal Transduction Toll-Like Receptors - metabolism |
| title | The immunomodulating role of exercise in metabolic disease |
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