THE TRYPANOCIDAL ACTIVITY OF SOME PYRIMIDYL‐AMINOPHENYLARSONIC COMPOUNDS

A series of substituted pyrimidylaminophenylarsonic acids have been prepared, reduced to the corresponding oxophenylarsines and finally, in certain cases, to the arsenobenzenes. The tervalent arsenicals were highly active against Trypanosoma rhodesiense in mice. 4‐(2:6‐Diaminopyrimid‐4‐ylamino)pheny...

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Bibliographic Details
Published in:British Journal of Pharmacology 1958-09, Vol.13 (3), p.244-249
Main Authors: AINLEY, A. D., DAVEY, D. G.
Format: Article
Language:English
Subjects:
Trypanosoma
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Summary:A series of substituted pyrimidylaminophenylarsonic acids have been prepared, reduced to the corresponding oxophenylarsines and finally, in certain cases, to the arsenobenzenes. The tervalent arsenicals were highly active against Trypanosoma rhodesiense in mice. 4‐(2:6‐Diaminopyrimid‐4‐ylamino)phenyloxoarsine either as the insoluble carbonate or the soluble isethionate was the most promising of these compounds.
ISSN:0366-0826
1476-5381
DOI:10.1111/j.1476-5381.1958.tb00898.x