Impact of Antiretroviral Therapy on Renal Function among HIV-Infected Tanzanian Adults: A Retrospective Cohort Study: e89573

Background Data regarding the outcomes of HIV-infected adults with baseline renal dysfunction who start antiretroviral therapy are conflicting. Methods We followed up a previously-published cohort of HIV-infected adult outpatients in northwest Tanzania who had high prevalence of renal dysfunction at...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2)
Main Authors: Mpondo, Bonaventura CT, Kalluvya, Samuel E, Peck, Robert N, Kabangila, Rodrick, Kidenya, Benson R, Ephraim, Lucheri, Fitzgerald, Daniel W, Downs, Jennifer A
Format: Article
Language:English
Subjects:
Human immunodeficiency virus
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Summary:Background Data regarding the outcomes of HIV-infected adults with baseline renal dysfunction who start antiretroviral therapy are conflicting. Methods We followed up a previously-published cohort of HIV-infected adult outpatients in northwest Tanzania who had high prevalence of renal dysfunction at the time of starting antiretroviral therapy (between November 2009 and February 2010). Patients had serum creatinine, proteinuria, microalbuminuria, and CD4+ T-cell count measured at the time of antiretroviral therapy initiation and at follow-up. We used the adjusted Cockroft-Gault equation to calculate estimated glomerular filtration rates (eGFRs). Results In this cohort of 171 adults who had taken antiretroviral therapy for a median of two years, the prevalence of renal dysfunction (eGFR
ISSN:1932-6203
DOI:10.1371/journal.pone.0089573