Variable alteration of regional tissue oxygen pressure in rat hippocampus by acute swimming exercise

One of the events in the brain is an increasing cerebral blood flow during exercise. The tissue oxygen level may be increased because blood flow correlates with tissue oxygen level. However, it is little known whether the tissue oxygen pressure in hippocampal region (Hip-pO2) will be affected by exe...

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Bibliographic Details
Published in:Life sciences (1973) 2013-11, Vol.93 (21), p.773-777
Main Authors: Gegentonglaga, Yoshizato, H., Higuchi, Y., Toyota, Y., Hanai, Y., Ando, Y., Yoshimura, A.
Format: Article
Language:English
Subjects:
Animals
blood flow
electrodes
Exercise
Exercise intensity
Hippocampus
Hippocampus - metabolism
Male
oxygen
Oxygen - metabolism
Oxygen pressure (pO2)
Physical Conditioning, Animal - physiology
Pressure
Rats
Rest - physiology
swimming
Swimming - physiology
Time Factors
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Summary:One of the events in the brain is an increasing cerebral blood flow during exercise. The tissue oxygen level may be increased because blood flow correlates with tissue oxygen level. However, it is little known whether the tissue oxygen pressure in hippocampal region (Hip-pO2) will be affected by exercise. The aim of this study is to examine Hip-pO2 levels in the hippocampus and its changes during exercise. We applied improved Clark-type electrodes to measure Hip-pO2 level in the hippocampus of rats that were subjected to three groups, 2h swimming without weights (low intensity, n=6), 2h swimming with a 5g weight (moderate intensity, n=6), and 2h swimming with a 10g weight (high intensity, n=6). Exercise affected the Hip-pO2 level, the responses varied with the exercise intensity and duration. Interestingly during and after the Low intensity swimming the Hip-pO2 level showed long lasting enhancement (10–20% above resting level). But the moderate and high intensity swimming increased Hip-pO2 level at the start of the swimming (50%, P
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2013.09.022