Insight into Tor2, a budding yeast microdomain protein

The plasma membrane of eukaryotic organisms is compartmentalized into microdomains. The budding yeast Saccharomyces cerevisiae presents three laterally distinct microdomains: membrane compartment containing Can1 (MCC), membrane compartment containing Pma1 (MCP), and membrane compartment containing T...

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Bibliographic Details
Published in:European journal of cell biology 2014-03, Vol.93 (3), p.87-97
Main Authors: Bartlett, Katelyn, Kim, Kyoungtae
Format: Article
Language:English
Subjects:
Actin Cytoskeleton - metabolism
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Membrane - metabolism
Endocytosis
Membrane organization
Microdomains
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae - ultrastructure
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Signal Transduction
Tor2
TORC2
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Summary:The plasma membrane of eukaryotic organisms is compartmentalized into microdomains. The budding yeast Saccharomyces cerevisiae presents three laterally distinct microdomains: membrane compartment containing Can1 (MCC), membrane compartment containing Pma1 (MCP), and membrane compartment containing Tor2 (MCT). Tor2 and its corresponding protein complex, target of rapamycin complex 2 (TORC2), has been of particular interest in recent years. Tor2, the main organizer of TORC2, is a highly conserved kinase that has proved to be an important regulator of multiple cellular functions including cell growth, actin polymerization, endocytosis, and sphingolipid synthesis. Despite significant advancements, the full understanding of the Tor2 signaling networks is incomplete. Here we review the most compelling evidences for the function and physiological significance of Tor2, as well as discuss possible implications and explanations for observed phenomena.
ISSN:0171-9335
1618-1298
DOI:10.1016/j.ejcb.2014.01.004