Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study

A series of eighteen novel 3,5-bis(arylidiene)-4-piperidone based symmetrical monocarbonyl analogs of curcumin were synthesised and a subset was screened by National Cancer Institute (NCI), USA for their anticancer activity. Dose–response studies and the mechanism of action investigation suggest tha...

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Bibliographic Details
Published in:MedChemComm 2014, Vol.5 (5), p.576-586
Main Authors: Thakur, Anuj, Manohar, Sunny, Vélez Gerena, Christian E., Zayas, Beatriz, Kumar, Vineet, Malhotra, Sanjay V., Rawat, Diwan S.
Format: Article
Language:English
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Summary:A series of eighteen novel 3,5-bis(arylidiene)-4-piperidone based symmetrical monocarbonyl analogs of curcumin were synthesised and a subset was screened by National Cancer Institute (NCI), USA for their anticancer activity. Dose–response studies and the mechanism of action investigation suggest that most active compounds are apoptosis inducers.
ISSN:2040-2503
2040-2511
DOI:10.1039/C3MD00399J