Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies

Highlights • A library composed of 156 sgRNAs was screened for blood cancer therapeutic agents. • Twenty sgRNAs efficiently induce apoptosis in leukemia and/or myeloma cells. • Four of the 20 sgRNAs reduce growth rates of HL60 cells in mouse xenograft models.

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Bibliographic Details
Published in:Leukemia research 2014-07, Vol.38 (7), p.808-815
Main Authors: Takahashi, Masayuki, Elbarbary, Reyad A, Watanabe, Norihiro, Goto, Atsushi, Kamiya, Daichi, Watabe, Yoshihiro, Uchiyama, Takayoshi, Narita, Miwako, Takahashi, Masuhiro, Takahashi, Yoshiaki, Ishihara, Noriko, Miyazawa, Tatsuya, Yoshida, Tetsuo, Kawano, Mitsuoki, Tamura, Masato, Nashimoto, Masayuki
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Endoribonucleases - genetics
Gene Library
Gene Silencing
Hematologic Neoplasms - therapy
Hematology, Oncology and Palliative Medicine
Humans
Leukemia
Male
Mice
Middle Aged
Multiple myeloma
Oligonucleotide Array Sequence Analysis
RNA therapy
RNA, Guide - metabolism
sgRNA
tRNase ZL
TRUE gene silencing
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Description
Summary:Highlights • A library composed of 156 sgRNAs was screened for blood cancer therapeutic agents. • Twenty sgRNAs efficiently induce apoptosis in leukemia and/or myeloma cells. • Four of the 20 sgRNAs reduce growth rates of HL60 cells in mouse xenograft models.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2014.03.021