Luliconazole: a review of a new antifungal agent for the topical treatment of onychomycosis

Summary Luliconazole is a novel, broad‐spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been fo...

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Bibliographic Details
Published in:Mycoses 2014-07, Vol.57 (7), p.389-393
Main Authors: Scher, Richard K., Nakamura, Norifumi, Tavakkol, Amir
Format: Article
Language:English
Subjects:
Administration, Topical
antifungal
Antifungal Agents - administration & dosage
dermatophyte
Foot Dermatoses - drug therapy
Humans
Imidazoles - administration & dosage
Luliconazole
onychomycosis
Onychomycosis - drug therapy
Pharmaceutical Solutions - administration & dosage
topical
Trichophyton rubrum
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Summary:Summary Luliconazole is a novel, broad‐spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections.
ISSN:0933-7407
1439-0507
DOI:10.1111/myc.12168