Overexpression of microRNA-155 predicts poor prognosis in glioma patients

MicroRNA-155 is highly expressed in many malignant tumors with poor prognosis, which regulates cell apoptosis, proliferation, invasion, metastasis, tumor angiogenesis, and metabolism. This study aims at investigating the clinical significance of miR-155 expression in human gliomas. Real-time quantit...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2014-04, Vol.31 (4), p.911-911, Article 911
Main Authors: Sun, Jun, Shi, Huachao, Lai, Niansheng, Liao, Keman, Zhang, Shuai, Lu, Xiaojie
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Apoptosis
Brain - pathology
Brain Neoplasms - diagnosis
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Disease Progression
Disease-Free Survival
Female
Gene Expression Regulation, Neoplastic
Glioma - diagnosis
Glioma - metabolism
Glioma - pathology
Hematology
Humans
Internal Medicine
Kaplan-Meier Estimate
Male
Medicine
Medicine & Public Health
MicroRNAs - metabolism
Middle Aged
Neoplasm Invasiveness
Oncology
Original Paper
Pathology
Prognosis
Proportional Hazards Models
Treatment Outcome
Young Adult
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Summary:MicroRNA-155 is highly expressed in many malignant tumors with poor prognosis, which regulates cell apoptosis, proliferation, invasion, metastasis, tumor angiogenesis, and metabolism. This study aims at investigating the clinical significance of miR-155 expression in human gliomas. Real-time quantitative PCR was used to detect the expression levels of miR-155 in 131 glioma and 16 normal brain tissues. The association of miR-155 expression with clinicopathological factors and prognosis of glioma patients were analyzed. The expression levels of miR-155 were significantly higher in glioma tissues than that in normal brain tissues ( P  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-014-0911-x