Analysis of the coverage capacity of the StreptInCor candidate vaccine against Streptococcus pyogenes

Highlights • Anti-StreptInCor antibodies are able to bind to several M proteins. • StreptInCor presented bacterial opsonophagocytic and neutralizing properties. • Anti-StreptInCor antibodies did not induce autoimmune reactions. • Specific antibodies cross recognized diverse M proteins.

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Bibliographic Details
Published in:Vaccine 2014-07, Vol.32 (32), p.4104-4110
Main Authors: De Amicis, Karine M, Freschi de Barros, Samar, Alencar, Raquel E, Postól, Edilberto, Martins, Carlo de Oliveira, Arcuri, Helen Andrade, Goulart, Cibelly, Kalil, Jorge, Guilherme, Luiza
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Bacterial - blood
Antibodies, Neutralizing - blood
Antigens, Bacterial - immunology
Applied microbiology
Autoimmunity
Bacteriology
Biological and medical sciences
Cross Reactions
Fundamental and applied biological sciences. Psychology
Humans
Immune response
Immunization coverage
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
Mitral Valve - immunology
Phagocytosis
Rheumatic fever
Streptococcal Infections - prevention & control
Streptococcal Vaccines - immunology
Streptococcus pyogenes
Vaccine
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Description
Summary:Highlights • Anti-StreptInCor antibodies are able to bind to several M proteins. • StreptInCor presented bacterial opsonophagocytic and neutralizing properties. • Anti-StreptInCor antibodies did not induce autoimmune reactions. • Specific antibodies cross recognized diverse M proteins.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.08.043