Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica

• Published in: European journal of pharmacology 2013-11, Vol.720 (1-3), p.286-293
• Main Authors: Viswanatha, G.L., Shylaja, H., Mohan, C.G.
• Format: Article
• Language: English
• Subjects: 1,2,3,4, 6-Penta-O-galloyl-β-d-glucopyranose; Animals; antioxidant activity; antioxidants; blood vessels; brain; Brain - drug effects; Brain - metabolism; Brain - pathology; Brain Injuries - drug therapy; Brain Injuries - metabolism; Brain Injuries - pathology; Brain Injuries - physiopathology; Brain Injuries - psychology; catalase; Catalase - metabolism; cognition; edema; glutathione; Hand Strength; histopathology; Hydrolyzable Tannins - pharmacology; Hydrolyzable Tannins - therapeutic use; infarction; ischemia; Ischemia/reperfusion; lipid peroxidation; Lipid Peroxidation - drug effects; Male; Mangifera; Mangifera indica; Maze Learning - drug effects; memory; Neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Oxidative stress; parenchyma; pharmacology; physical activity; Postural Balance - drug effects; pretreatment; protective effect; quercetin; Rats; Rats, Wistar; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Reperfusion Injury - physiopathology; Reperfusion Injury - psychology; Stroke; superoxide dismutase; Superoxide Dismutase - metabolism
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2013.10.016

Present study was undertaken to evaluate the protective effect of 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose (PGG) against transient global ischemia/reperfusion (I/R)-induced brain injury in rats. Sixty minutes of global ischemia, followed by 24h of reperfusion caused significant alterations in cognition and memory (p