Acoustic behavior of microbubbles and implications for drug delivery

Ultrasound contrast agents are valuable in diagnostic ultrasound imaging, and they increasingly show potential for drug delivery. This review focuses on the acoustic behavior of flexible-coated microbubbles and rigid-coated microcapsules and their contribution to enhanced drug delivery. Phenomena re...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2014-06, Vol.72, p.28-48
Main Authors: Kooiman, Klazina, Vos, Hendrik J., Versluis, Michel, de Jong, Nico
Format: Article
Language:English
Subjects:
Acoustic cavitation
Acoustic microstreaming
Acoustics
Animals
Co-administration
Drug carrier system
Drug Delivery Systems
Drug release
Drug uptake
Humans
Microbubbles
Microcapsule
Ultrasound contrast agent
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Summary:Ultrasound contrast agents are valuable in diagnostic ultrasound imaging, and they increasingly show potential for drug delivery. This review focuses on the acoustic behavior of flexible-coated microbubbles and rigid-coated microcapsules and their contribution to enhanced drug delivery. Phenomena relevant to drug delivery, such as non-spherical oscillations, shear stress, microstreaming, and jetting will be reviewed from both a theoretical and experimental perspective. Further, the two systems for drug delivery, co-administration and the microbubble as drug carrier system, are reviewed in relation to the microbubble behavior. Finally, future prospects are discussed that need to be addressed for ultrasound contrast agents to move from a pre-clinical tool into a clinical setting. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2014.03.003