Ultrastructural analysis of pancreatic carcinogenesis. V. Changes in differentiation of acinar cells during chronic treatment with N-nitrosobis(2-hydroxypropyl)amine

An electron microscope study was carried out on changes in the pancreatic acinar tissues of male Syrian hamsters during the course of induction of pancreatic neoplasia by lifetime weeky injections of N nitroso bis(2 hydroxypropyl)amine (BHP). The dominant process observed was a loss of differentiati...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1982, Vol.3 (5), p.485-498
Main Authors: Flaks, Bojan, Moore, Malcolm A., Flaks, Antonia
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemically induced
Adenocarcinoma - ultrastructure
Animals
Cell Transformation, Neoplastic - chemically induced
Cell Transformation, Neoplastic - ultrastructure
Cells, Cultured
Cricetinae
Endoplasmic Reticulum - ultrastructure
Golgi Apparatus - ultrastructure
Male
Microscopy, Electron
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - ultrastructure
Nitrosamines - toxicity
Pancreas - drug effects
Pancreas - ultrastructure
Pancreatic Neoplasms - chemically induced
Pancreatic Neoplasms - ultrastructure
Time Factors
Citations: Items that cite this one
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Summary:An electron microscope study was carried out on changes in the pancreatic acinar tissues of male Syrian hamsters during the course of induction of pancreatic neoplasia by lifetime weeky injections of N nitroso bis(2 hydroxypropyl)amine (BHP). The dominant process observed was a loss of differentiation of the acinar cells, leading to the development of a new population of cells that closely resemble centro acinar or ductular cells. During this process, the original centroacinar and ductular cells appear to be relatively unaffected by exposure to BHP. Thus, acinar cell de differentiation appears, in this experimental model, to be an important preliminary stage in neoplastic development. It is argued that these findings may have implications for the histogenesis of human pancreatic adenocarcinoma, considered hitherto to be ductal in origin.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/3.5.485