Arsenic oxide-induced thermotolerance in Saccharomyces cerevisiae

The growth response of Saccharomyces cerevisiae to arsenite and arsenate and the relationship between the enhancement of heat shock protein (hsp) synthesis caused by these arsenic oxides and thermotolerance are reported. Arsenite and arsenate transiently inhibited cell growth and overall protein syn...

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Bibliographic Details
Published in:Journal of Bacteriology 1989-11, Vol.171 (11), p.6349-6352
Main Authors: Chang, E.C. (State University of New York at Buffalo, Buffalo, NY), Kosman, D.J, Willsky, G.R
Format: Article
Language:English
Subjects:
Action of physical and chemical agents
Arsenates - pharmacology
ARSENIC
Arsenic - pharmacology
Arsenic Trioxide
Arsenicals
ARSENICO
Arsenites
Biological and medical sciences
CALOR
CHALEUR
Fundamental and applied biological sciences. Psychology
Heat-Shock Proteins - biosynthesis
Heat-Shock Proteins - isolation & purification
HERBICIDAS
HERBICIDE
Hot Temperature
Kinetics
Methionine
Microbiology
Mycology
Oxides
RESISTANCE A LA TEMPERATURE
RESISTENCIA A LA TEMPERATURA
SACCHAROMYCES CEREVISIAE
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - growth & development
SALES
SEL
SINTESIS DE PROTEINAS
STRESS
SYNTHESE PROTEIQUE
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Summary:The growth response of Saccharomyces cerevisiae to arsenite and arsenate and the relationship between the enhancement of heat shock protein (hsp) synthesis caused by these arsenic oxides and thermotolerance are reported. Arsenite and arsenate transiently inhibited cell growth and overall protein synthesis; arsenate enhanced the synthesis of the 42-, 74-, 84-, and 100-kilodalton hsps, whereas arsenite enhanced synthesis of only the 74-kilodalton hsp. The induction of these hsps reached a maximum 45 min following metal oxide treatment and then declined. A delayed thermotolerance peaked 4 h after metal oxide addition, at which time cell growth and protein synthesis were recovering. These data show that the arsenate- and arsenite-induced thermotolerance in S. cerevisiae cells does not appear to be causally related to either hsp synthesis or cell cycle arrest
ISSN:0021-9193
1098-5530
1067-8832
DOI:10.1128/jb.171.11.6349-6352.1989