A blunted anxiolytic like effect of curcumin against acute lead induced anxiety in rat: Involvement of serotonin

Anxiety is one of the most common mental disorders sharing extreme or pathological anxiety states as the primary disturbance in mood or emotional tone, with increased fear and exaggerated acute stress responses. Medicinal plants are very variable, but some of them are used as a spice such as curcumi...

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Bibliographic Details
Published in:Acta histochemica 2014-06, Vol.116 (5), p.920-925
Main Authors: Benammi, Hind, El Hiba, Omar, Romane, Abderrahmane, Gamrani, Halima
Format: Article
Language:English
Subjects:
Animals
Anti-Anxiety Agents - pharmacology
Anti-Anxiety Agents - therapeutic use
Anxiety
Anxiety Disorders - chemically induced
Anxiety Disorders - drug therapy
Curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Dorsal raphe nucleus
Dorsal Raphe Nucleus - drug effects
Gene Expression Regulation - drug effects
Immunohistochemistry
Lead
Lead intoxication
Male
Rat
Rats
Rats, Wistar
Serotonin
Serotonin - genetics
Serotonin - metabolism
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Summary:Anxiety is one of the most common mental disorders sharing extreme or pathological anxiety states as the primary disturbance in mood or emotional tone, with increased fear and exaggerated acute stress responses. Medicinal plants are very variable, but some of them are used as a spice such as curcumin (Curcuma longa). Curcumin shows a wide range of pharmacological potentialities, however, little is known about its anxiolytic properties. The aim of our study was to assess the anti-anxiety potential of curcumin extract against experimental lead induced-anxiety in rats. Experiments were carried out on male Wistar rats intoxicated acutely with an intraperitoneal injection of Pb (25mg/kg B.W.) and/or concomitantly with administration of curcumin (30mg/kg B.W.) for 3 days. Using immunohistochemistry and anxiety assessment tests (dark light box and elevated plus maze), we evaluated, respectively, the expression of serotonin (5HT) in the dorsal raphe nucleus (DRN) and the anxiety state in our animals. Our results showed, for the first time, a noticeable anxiolytic effect of curcumin against lead induced anxiety in rats and this may possibly result from modulation of central neuronal monoaminergic neurotransmission, especially serotonin, which has shown a significant reduction of the immunoreactivity within the DRN.
ISSN:0065-1281
1618-0372
DOI:10.1016/j.acthis.2014.03.002