Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques

Abstract Aims Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. Methods and results We used one of the largest biobanks, the Athero-Express study ( n = 1455) at carotid endarterectomy (CE...

Full description

Saved in:
Bibliographic Details
Published in:Atherosclerosis 2014-08, Vol.235 (2), p.418-423
Main Authors: Scholtes, Vincent P.W, Peeters, Wouter, van Lammeren, Guus W, Howard, Dominic P.J, de Vries, Jean-Paul P.M, de Borst, Gert Jan, Redgrave, Jessica N, Kemperman, Hans, Schalkwijk, Casper G, den Ruijter, Hester M, de Kleijn, Dominique P.V, Moll, Frans L, Rothwell, Peter M, Pasterkamp, Gerard
Format: Article
Language:English
Subjects:
Cardiovascular
Carotid endarterectomy
Carotid plaque
Diabetes
Diabetes Mellitus, Type 2 - complications
Endarterectomy, Carotid
Histology
Plaque, Atherosclerotic - pathology
Plaque, Atherosclerotic - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Aims Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. Methods and results We used one of the largest biobanks, the Athero-Express study ( n = 1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabetic patients. Conclusion In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2014.05.941