Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients

The frequency of spontaneous 6-thioguanine (TG)-resistant peripheral blood lymphocytes in five unrelated Werner syndrome (WS) patients was determined using an autoradiographic labeling assay. The average frequency of TG-resistant lymphocytes was eightfold higher in WS patients than in sex- and age-m...

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Bibliographic Details
Published in:Human genetics 1990-02, Vol.84 (3), p.249-252
Main Authors: Fukuchi, K, Tanaka, K, Kumahara, Y, Marumo, K, Pride, M B, Martin, G M, Monnat, Jr, R J
Format: Article
Language:English
Subjects:
6-thioguanine
Adult
Cells, Cultured
Drug Resistance
Female
Humans
lymphocytes
Lymphocytes - drug effects
Male
Middle Aged
Mutation
Thioguanine - toxicity
Werner Syndrome - genetics
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Summary:The frequency of spontaneous 6-thioguanine (TG)-resistant peripheral blood lymphocytes in five unrelated Werner syndrome (WS) patients was determined using an autoradiographic labeling assay. The average frequency of TG-resistant lymphocytes was eightfold higher in WS patients than in sex- and age-matched normal control donors. This finding and previous identification of increased spontaneous chromosomal rearrangements and deletions in WS cells or cell lines suggest that WS is a human genomic instability or mutator syndrome.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00200569