Hemin Lyses Malaria Parasites

Malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin IX chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. This effect of hemin may explain the protection agai...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-11, Vol.214 (4521), p.667-669
Main Authors: Orjih, Augustine U., Banyal, H. S., Chevli, Rekha, Fitch, Coy D.
Format: Article
Language:English
Subjects:
Agricultural soils
Animals
Blood diseases
Carbohydrates
Chemical suspensions
Chloroquine - pharmacology
Clay soils
Drug Interactions
Drug Resistance
Erythrocytes
Hematologic diseases
Heme - analogs & derivatives
Hemin - pharmacology
Hemoglobin
Hemoglobins
Luteinization
Malaria
Mice
Parasites
Plasmodium
Plasmodium berghei - drug effects
Soil microorganisms
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Summary:Malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin IX chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. This effect of hemin may explain the protection against malaria provided by thalassemia and other conditions causing intracellular denaturation of hemoglobin. The toxicity of the chloroquine-hemin complex may explain the selective antimalarial action of chloroquine.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7027441