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Assessment of skin photoaging with reflectance confocal microscopy
Background/Purpose Increased interest in antiaging methods, mandates a development of reliable noninvasive technique to assess skin aging. In this study, we aimed to determine the effects of photoaging at histopathologic resolution by means of reflectance confocal microscopy. Method The sun‐exposed...
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Published in: | Skin research and technology 2014-08, Vol.20 (3), p.363-372 |
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creator | Kutlu Haytoglu, N. S. Gurel, M. S. Erdemir, A. Falay, T. Dolgun, A. Haytoglu, T. G. |
description | Background/Purpose
Increased interest in antiaging methods, mandates a development of reliable noninvasive technique to assess skin aging. In this study, we aimed to determine the effects of photoaging at histopathologic resolution by means of reflectance confocal microscopy.
Method
The sun‐exposed malar area, the anterior aspect of ear lobule, and the sun‐protected posterior aspect of ear lobule had been evaluated in 120 volunteers from different age groups over 10 previously reported and new confocal parameters for skin aging.
Result
The sun‐exposed areas revealed more frequent irregular honeycomb pattern, polycylic papillary contours, coarse collagen, huddled collagen, curled bright structures with higher epidermal thickness, and furrow depth values. However, the incidence of thin reticulated collagen and the number of dermal papillae were statistically higher on the sun‐protected posterior aspect of ear lobule.
Conclusion
Reflectance confocal microscopy is a reliable diagnostic technique for evaluation of skin photoaging with objective criteria. With the new emerging compact models it is possible to scan even the least accessible body parts with no discomfort to the patient, which offers the possibility to assess the effect of antiaging applications and to identify early signs of solar damage in cosmetically sensitive areas. |
doi_str_mv | 10.1111/srt.12127 |
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Increased interest in antiaging methods, mandates a development of reliable noninvasive technique to assess skin aging. In this study, we aimed to determine the effects of photoaging at histopathologic resolution by means of reflectance confocal microscopy.
Method
The sun‐exposed malar area, the anterior aspect of ear lobule, and the sun‐protected posterior aspect of ear lobule had been evaluated in 120 volunteers from different age groups over 10 previously reported and new confocal parameters for skin aging.
Result
The sun‐exposed areas revealed more frequent irregular honeycomb pattern, polycylic papillary contours, coarse collagen, huddled collagen, curled bright structures with higher epidermal thickness, and furrow depth values. However, the incidence of thin reticulated collagen and the number of dermal papillae were statistically higher on the sun‐protected posterior aspect of ear lobule.
Conclusion
Reflectance confocal microscopy is a reliable diagnostic technique for evaluation of skin photoaging with objective criteria. With the new emerging compact models it is possible to scan even the least accessible body parts with no discomfort to the patient, which offers the possibility to assess the effect of antiaging applications and to identify early signs of solar damage in cosmetically sensitive areas.</description><identifier>ISSN: 0909-752X</identifier><identifier>EISSN: 1600-0846</identifier><identifier>DOI: 10.1111/srt.12127</identifier><identifier>PMID: 24506234</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging - physiology ; Collagen ; collagen changes ; Dermoscopy - methods ; elastosis ; Female ; Humans ; Image Interpretation, Computer-Assisted - methods ; Male ; Microscopy ; Microscopy, Confocal - methods ; Microscopy, Interference - methods ; Middle Aged ; noninvasive imaging ; photoaging ; reflectance confocal microscopy ; Reproducibility of Results ; Sensitivity and Specificity ; Skin ; Skin - cytology ; Skin - radiation effects ; skin aging ; Skin Aging - physiology ; Sunlight ; Wound healing</subject><ispartof>Skin research and technology, 2014-08, Vol.20 (3), p.363-372</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4617-13a2e3b3b5209fe26ffe19f664209bf8b7cdb789246a0003d246ac33ea28de383</citedby><cites>FETCH-LOGICAL-c4617-13a2e3b3b5209fe26ffe19f664209bf8b7cdb789246a0003d246ac33ea28de383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsrt.12127$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsrt.12127$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,11562,27924,27925,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fsrt.12127$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24506234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kutlu Haytoglu, N. S.</creatorcontrib><creatorcontrib>Gurel, M. S.</creatorcontrib><creatorcontrib>Erdemir, A.</creatorcontrib><creatorcontrib>Falay, T.</creatorcontrib><creatorcontrib>Dolgun, A.</creatorcontrib><creatorcontrib>Haytoglu, T. G.</creatorcontrib><title>Assessment of skin photoaging with reflectance confocal microscopy</title><title>Skin research and technology</title><addtitle>Skin Res Technol</addtitle><description>Background/Purpose
Increased interest in antiaging methods, mandates a development of reliable noninvasive technique to assess skin aging. In this study, we aimed to determine the effects of photoaging at histopathologic resolution by means of reflectance confocal microscopy.
Method
The sun‐exposed malar area, the anterior aspect of ear lobule, and the sun‐protected posterior aspect of ear lobule had been evaluated in 120 volunteers from different age groups over 10 previously reported and new confocal parameters for skin aging.
Result
The sun‐exposed areas revealed more frequent irregular honeycomb pattern, polycylic papillary contours, coarse collagen, huddled collagen, curled bright structures with higher epidermal thickness, and furrow depth values. However, the incidence of thin reticulated collagen and the number of dermal papillae were statistically higher on the sun‐protected posterior aspect of ear lobule.
Conclusion
Reflectance confocal microscopy is a reliable diagnostic technique for evaluation of skin photoaging with objective criteria. With the new emerging compact models it is possible to scan even the least accessible body parts with no discomfort to the patient, which offers the possibility to assess the effect of antiaging applications and to identify early signs of solar damage in cosmetically sensitive areas.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Collagen</subject><subject>collagen changes</subject><subject>Dermoscopy - methods</subject><subject>elastosis</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Male</subject><subject>Microscopy</subject><subject>Microscopy, Confocal - methods</subject><subject>Microscopy, Interference - methods</subject><subject>Middle Aged</subject><subject>noninvasive imaging</subject><subject>photoaging</subject><subject>reflectance confocal microscopy</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Skin</subject><subject>Skin - cytology</subject><subject>Skin - radiation effects</subject><subject>skin aging</subject><subject>Skin Aging - physiology</subject><subject>Sunlight</subject><subject>Wound healing</subject><issn>0909-752X</issn><issn>1600-0846</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kE1Lw0AQhhdRbP04-Ack4EUP0f3e5KhFq6AVtKK3ZbOd1WiSrdkU7b93a7UHwbnMDDzz8s6L0B7BxyTWSWi7Y0IJVWuoTyTGKc64XEd9nOM8VYI-9dBWCK8YY5ETtol6lAssKeN9dHYaAoRQQ9Ml3iXhrWyS6YvvvHkum-fko-xekhZcBbYzjYXE-sZ5a6qkLm3rg_XT-Q7acKYKsPvTt9HDxfl4cJle3w6vBqfXqeWSqJQwQ4EVrBAU5w6odA5I7qTkcS9cVig7KVSWUy5NdMomi8EyBoZmE2AZ20aHS91p699nEDpdl8FCVZkG_CxoIrgSJCcZj-jBH_TVz9omultQnBGVCxypoyW1-CTEL_W0LWvTzjXBehGsjsHq72Aju_-jOCtqmKzI3yQjcLIEPsoK5v8r6fu78a9kurwoQwefqwvTvmmpmBL6cTTU9wNBh8PRjb5jX-CbkII</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Kutlu Haytoglu, N. S.</creator><creator>Gurel, M. S.</creator><creator>Erdemir, A.</creator><creator>Falay, T.</creator><creator>Dolgun, A.</creator><creator>Haytoglu, T. G.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Assessment of skin photoaging with reflectance confocal microscopy</title><author>Kutlu Haytoglu, N. S. ; Gurel, M. S. ; Erdemir, A. ; Falay, T. ; Dolgun, A. ; Haytoglu, T. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4617-13a2e3b3b5209fe26ffe19f664209bf8b7cdb789246a0003d246ac33ea28de383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Collagen</topic><topic>collagen changes</topic><topic>Dermoscopy - methods</topic><topic>elastosis</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Male</topic><topic>Microscopy</topic><topic>Microscopy, Confocal - methods</topic><topic>Microscopy, Interference - methods</topic><topic>Middle Aged</topic><topic>noninvasive imaging</topic><topic>photoaging</topic><topic>reflectance confocal microscopy</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Skin</topic><topic>Skin - cytology</topic><topic>Skin - radiation effects</topic><topic>skin aging</topic><topic>Skin Aging - physiology</topic><topic>Sunlight</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kutlu Haytoglu, N. S.</creatorcontrib><creatorcontrib>Gurel, M. S.</creatorcontrib><creatorcontrib>Erdemir, A.</creatorcontrib><creatorcontrib>Falay, T.</creatorcontrib><creatorcontrib>Dolgun, A.</creatorcontrib><creatorcontrib>Haytoglu, T. G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Skin research and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kutlu Haytoglu, N. S.</au><au>Gurel, M. S.</au><au>Erdemir, A.</au><au>Falay, T.</au><au>Dolgun, A.</au><au>Haytoglu, T. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of skin photoaging with reflectance confocal microscopy</atitle><jtitle>Skin research and technology</jtitle><addtitle>Skin Res Technol</addtitle><date>2014-08</date><risdate>2014</risdate><volume>20</volume><issue>3</issue><spage>363</spage><epage>372</epage><pages>363-372</pages><issn>0909-752X</issn><eissn>1600-0846</eissn><abstract>Background/Purpose
Increased interest in antiaging methods, mandates a development of reliable noninvasive technique to assess skin aging. In this study, we aimed to determine the effects of photoaging at histopathologic resolution by means of reflectance confocal microscopy.
Method
The sun‐exposed malar area, the anterior aspect of ear lobule, and the sun‐protected posterior aspect of ear lobule had been evaluated in 120 volunteers from different age groups over 10 previously reported and new confocal parameters for skin aging.
Result
The sun‐exposed areas revealed more frequent irregular honeycomb pattern, polycylic papillary contours, coarse collagen, huddled collagen, curled bright structures with higher epidermal thickness, and furrow depth values. However, the incidence of thin reticulated collagen and the number of dermal papillae were statistically higher on the sun‐protected posterior aspect of ear lobule.
Conclusion
Reflectance confocal microscopy is a reliable diagnostic technique for evaluation of skin photoaging with objective criteria. With the new emerging compact models it is possible to scan even the least accessible body parts with no discomfort to the patient, which offers the possibility to assess the effect of antiaging applications and to identify early signs of solar damage in cosmetically sensitive areas.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24506234</pmid><doi>10.1111/srt.12127</doi><tpages>10</tpages></addata></record> |
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subjects | Adult Aged Aged, 80 and over Aging - physiology Collagen collagen changes Dermoscopy - methods elastosis Female Humans Image Interpretation, Computer-Assisted - methods Male Microscopy Microscopy, Confocal - methods Microscopy, Interference - methods Middle Aged noninvasive imaging photoaging reflectance confocal microscopy Reproducibility of Results Sensitivity and Specificity Skin Skin - cytology Skin - radiation effects skin aging Skin Aging - physiology Sunlight Wound healing |
title | Assessment of skin photoaging with reflectance confocal microscopy |
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