Prospective evaluation of metabolic syndrome and its components among long-term liver recipients

• Published in: Liver international 2014-08, Vol.34 (7), p.1094-1101
• Main Authors: Anastácio, Lucilene R., Diniz, Kiara G., Ribeiro, Hélem S., Ferreira, Lívia G., Lima, Agnaldo S., Correia, Maria Isabel T. D., Vilela, Eduardo G.
• Format: Article
• Language: English
• Subjects: Blood Glucose - metabolism; Body Composition - physiology; Brazil - epidemiology; Demography; diabetes mellitus; Diet; Electric Impedance; Humans; immunosuppressive agents; Life Style; liver transplantation; Liver Transplantation - adverse effects; Logistic Models; metabolic syndrome; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; obesity; Odds Ratio; Prevalence; Prospective Studies; Risk Factors; Socioeconomic Factors; Waist Circumference
• ISSN: 1478-3223; 1478-3231
• DOI: 10.1111/liv.12495

Background & Aims Survival after liver transplantation (LTx) has increased. Metabolic syndrome (MS) is widely reported in patients in the early years after LTx; few studies have researched this condition in relatively long‐term liver recipients. To describe, prospectively, the prevalence of MS, its components and its associated factors in relatively long‐term liver recipients. Methods A total of 117 patients were evaluated in 2008 (median of 3 years after LTx, range 0–13 years) and in 2012 (median of 7 years after LTx, range 3–17 years) for the presence of MS [using modified NCEP Adult Treatment Panel III and International Diabetes Federation (IDF) criteria]; its components; and its associated factors, including demographic, socioeconomic, lifestyle, clinical, body composition (measured using bioelectric impedance) and dietetic factors. Results MS increased over the years (IDF, 43.1–53.3%, P = 0.12; and NCEP, 34.3–44.8%, P = 0.03). Blood glucose increased over the years (98.8 ± 24.7 to 109.2 ± 33.3 mg/dl, P