Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients

Summary Objective A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet. Design Ninety‐three Caucasian ad...

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Published in:Clinical endocrinology (Oxford) 2014-08, Vol.81 (2), p.306-311
Main Authors: de la Iglesia, Rocio, Lopez-Legarrea, Patricia, Crujeiras, Ana B., Pardo, Maria, Casanueva, Felipe F., Zulet, Maria A., Martinez, Jose A.
Format: Article
Language:English
Subjects:
Apolipoproteins B - blood
Biological and medical sciences
Cholesterol - blood
Diet, Reducing
Endocrinopathies
Female
Fibronectins - blood
Fundamental and applied biological sciences. Psychology
Humans
Lipids - blood
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
Male
Medical sciences
Metabolic diseases
Metabolic Syndrome - blood
Miscellaneous
Other metabolic disorders
Vertebrates: endocrinology
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Summary:Summary Objective A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet. Design Ninety‐three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8‐week‐long energy‐restricted programme (−30% of the energy requirements). Anthropometric measurements, biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention. Results Global plasma irisin levels were significantly reduced at the end of the study (−72·0 ± 100·9 ng/ml, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.12383