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Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
Summary Objective A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet. Design Ninety‐three Caucasian ad...
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| Published in: | Clinical endocrinology (Oxford) 2014-08, Vol.81 (2), p.306-311 |
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| Main Authors: | , , , , , , |
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| container_title | Clinical endocrinology (Oxford) |
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| creator | de la Iglesia, Rocio Lopez-Legarrea, Patricia Crujeiras, Ana B. Pardo, Maria Casanueva, Felipe F. Zulet, Maria A. Martinez, Jose A. |
| description | Summary
Objective
A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet.
Design
Ninety‐three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8‐week‐long energy‐restricted programme (−30% of the energy requirements). Anthropometric measurements, biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention.
Results
Global plasma irisin levels were significantly reduced at the end of the study (−72·0 ± 100·9 ng/ml, P |
| doi_str_mv | 10.1111/cen.12383 |
| format | article |
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Objective
A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet.
Design
Ninety‐three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8‐week‐long energy‐restricted programme (−30% of the energy requirements). Anthropometric measurements, biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention.
Results
Global plasma irisin levels were significantly reduced at the end of the study (−72·0 ± 100·9 ng/ml, P < 0·001) accompanying the weight loss (−6·9%). The depletion of irisin significantly correlated with changes in some atherogenic‐related variables: total cholesterol (B = 0·106, P = 0·018), total cholesterol/high‐density lipoprotein cholesterol ratio (B = 0·002, P = 0·036), low‐density lipoprotein cholesterol (B = 0·085, P = 0·037) and apolipoprotein B (B = 0·052, P = 0·002), independently of changes in body weight.
Conclusions
An association between the reduction in plasma irisin levels and the depletion of important lipid metabolism biomarkers was observed in patients with MetS undergoing an energy‐restricted programme.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12383</identifier><identifier>PMID: 24325584</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Apolipoproteins B - blood ; Biological and medical sciences ; Cholesterol - blood ; Diet, Reducing ; Endocrinopathies ; Female ; Fibronectins - blood ; Fundamental and applied biological sciences. Psychology ; Humans ; Lipids - blood ; Lipoproteins, HDL - blood ; Lipoproteins, LDL - blood ; Male ; Medical sciences ; Metabolic diseases ; Metabolic Syndrome - blood ; Miscellaneous ; Other metabolic disorders ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2014-08, Vol.81 (2), p.306-311</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2013 John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5263-b90d1452dce8375ceb0ec0c071f2c7defb1dd8865ad724fcea401d734848657f3</citedby><cites>FETCH-LOGICAL-c5263-b90d1452dce8375ceb0ec0c071f2c7defb1dd8865ad724fcea401d734848657f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28613651$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24325584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de la Iglesia, Rocio</creatorcontrib><creatorcontrib>Lopez-Legarrea, Patricia</creatorcontrib><creatorcontrib>Crujeiras, Ana B.</creatorcontrib><creatorcontrib>Pardo, Maria</creatorcontrib><creatorcontrib>Casanueva, Felipe F.</creatorcontrib><creatorcontrib>Zulet, Maria A.</creatorcontrib><creatorcontrib>Martinez, Jose A.</creatorcontrib><title>Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Objective
A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet.
Design
Ninety‐three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8‐week‐long energy‐restricted programme (−30% of the energy requirements). Anthropometric measurements, biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention.
Results
Global plasma irisin levels were significantly reduced at the end of the study (−72·0 ± 100·9 ng/ml, P < 0·001) accompanying the weight loss (−6·9%). The depletion of irisin significantly correlated with changes in some atherogenic‐related variables: total cholesterol (B = 0·106, P = 0·018), total cholesterol/high‐density lipoprotein cholesterol ratio (B = 0·002, P = 0·036), low‐density lipoprotein cholesterol (B = 0·085, P = 0·037) and apolipoprotein B (B = 0·052, P = 0·002), independently of changes in body weight.
Conclusions
An association between the reduction in plasma irisin levels and the depletion of important lipid metabolism biomarkers was observed in patients with MetS undergoing an energy‐restricted programme.</description><subject>Apolipoproteins B - blood</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - blood</subject><subject>Diet, Reducing</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fibronectins - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Lipoproteins, HDL - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic Syndrome - blood</subject><subject>Miscellaneous</subject><subject>Other metabolic disorders</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kU9rFTEUxYMo9lld-AUkIIJdTJv_M13Ko7ZCWwsqLkMmuaOpmcyYzFjfzo9upu-1BcFsAie_e8_NPQi9pOSQlnNkIR5Sxhv-CK0oV7JiTMnHaEU4IRVRSuyhZzlfE0JkQ-qnaI8JzqRsxAr9uQom9wb75LOP2MEYYPJDxHN0kDBESN82OEGekre3Dz5jk_NgvZnA4Rs_fce-H9PwC3qIU8alS_Cjd7honQ-wCD1Mph2CtzhvoktDD3g0k1_45-hJZ0KGF7t7H315f_J5fVadfzz9sH53XlnJFK_aY-KokMxZaHgtLbQELLGkph2ztYOupc41jZLG1Ux0Fowg1NVcNKKIdcf30dtt3zLWz7n8R_c-WwjBRBjmrKkUtWRMClHQ1_-g18OcYpluoSQ7bqiihTrYUjYNOSfo9Jh8b9JGU6KXWHSJRd_GUthXu45z24O7J-9yKMCbHWCyNaFLJlqfH7hGLbkupkdb7qZsdvN_R70-ubyzrrYVPk_w-77CpB9a1WWT-uvlqb6gn4SQSuor_hc9jbTD</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>de la Iglesia, Rocio</creator><creator>Lopez-Legarrea, Patricia</creator><creator>Crujeiras, Ana B.</creator><creator>Pardo, Maria</creator><creator>Casanueva, Felipe F.</creator><creator>Zulet, Maria A.</creator><creator>Martinez, Jose A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients</title><author>de la Iglesia, Rocio ; Lopez-Legarrea, Patricia ; Crujeiras, Ana B. ; Pardo, Maria ; Casanueva, Felipe F. ; Zulet, Maria A. ; Martinez, Jose A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5263-b90d1452dce8375ceb0ec0c071f2c7defb1dd8865ad724fcea401d734848657f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Apolipoproteins B - blood</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - blood</topic><topic>Diet, Reducing</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fibronectins - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Lipoproteins, HDL - blood</topic><topic>Lipoproteins, LDL - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic Syndrome - blood</topic><topic>Miscellaneous</topic><topic>Other metabolic disorders</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de la Iglesia, Rocio</creatorcontrib><creatorcontrib>Lopez-Legarrea, Patricia</creatorcontrib><creatorcontrib>Crujeiras, Ana B.</creatorcontrib><creatorcontrib>Pardo, Maria</creatorcontrib><creatorcontrib>Casanueva, Felipe F.</creatorcontrib><creatorcontrib>Zulet, Maria A.</creatorcontrib><creatorcontrib>Martinez, Jose A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de la Iglesia, Rocio</au><au>Lopez-Legarrea, Patricia</au><au>Crujeiras, Ana B.</au><au>Pardo, Maria</au><au>Casanueva, Felipe F.</au><au>Zulet, Maria A.</au><au>Martinez, Jose A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2014-08</date><risdate>2014</risdate><volume>81</volume><issue>2</issue><spage>306</spage><epage>311</epage><pages>306-311</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective
A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet.
Design
Ninety‐three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8‐week‐long energy‐restricted programme (−30% of the energy requirements). Anthropometric measurements, biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention.
Results
Global plasma irisin levels were significantly reduced at the end of the study (−72·0 ± 100·9 ng/ml, P < 0·001) accompanying the weight loss (−6·9%). The depletion of irisin significantly correlated with changes in some atherogenic‐related variables: total cholesterol (B = 0·106, P = 0·018), total cholesterol/high‐density lipoprotein cholesterol ratio (B = 0·002, P = 0·036), low‐density lipoprotein cholesterol (B = 0·085, P = 0·037) and apolipoprotein B (B = 0·052, P = 0·002), independently of changes in body weight.
Conclusions
An association between the reduction in plasma irisin levels and the depletion of important lipid metabolism biomarkers was observed in patients with MetS undergoing an energy‐restricted programme.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>24325584</pmid><doi>10.1111/cen.12383</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2014-08, Vol.81 (2), p.306-311 |
| issn | 0300-0664 1365-2265 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Apolipoproteins B - blood Biological and medical sciences Cholesterol - blood Diet, Reducing Endocrinopathies Female Fibronectins - blood Fundamental and applied biological sciences. Psychology Humans Lipids - blood Lipoproteins, HDL - blood Lipoproteins, LDL - blood Male Medical sciences Metabolic diseases Metabolic Syndrome - blood Miscellaneous Other metabolic disorders Vertebrates: endocrinology |
| title | Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients |
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