Diagnostic yield of transbronchial cryobiopsy in interstitial lung disease: A randomized trial

Background and objective Transbronchial lung biopsy (TBLB) is required for evaluation in selected patients with interstitial lung disease (ILD). The diagnostic yield of histopathologic assessment is variable and is influenced by factors such as the size of samples and the presence of crush artefacts...

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Published in:Respirology (Carlton, Vic.) Vic.), 2014-08, Vol.19 (6), p.900-906
Main Authors: Pajares, Virginia, Puzo, Carmen, Castillo, Diego, Lerma, Enrique, Montero, M. Angeles, Ramos-Barbón, David, Amor-Carro, Oscar, Gil de Bernabé, Angels, Franquet, Tomás, Plaza, Vicente, Hetzel, Jürgen, Sanchis, Joaquin, Torrego, Alfons
Format: Article
Language:English
Subjects:
Aged
Biopsy - adverse effects
Biopsy - instrumentation
Biopsy - methods
bronchoscopy
Bronchoscopy - adverse effects
Bronchoscopy - instrumentation
Bronchoscopy - methods
cryobiopsy
Cryopreservation - instrumentation
Cryopreservation - methods
cryoprobe
Female
Hemorrhage - epidemiology
Hemorrhage - etiology
Histological Techniques - instrumentation
Histological Techniques - methods
Humans
Incidence
interstitial lung disease
Lung - pathology
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - pathology
Male
Middle Aged
Outcome Assessment (Health Care)
Reproducibility of Results
Surgical Instruments
transbronchial lung biopsy
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Summary:Background and objective Transbronchial lung biopsy (TBLB) is required for evaluation in selected patients with interstitial lung disease (ILD). The diagnostic yield of histopathologic assessment is variable and is influenced by factors such as the size of samples and the presence of crush artefacts left by conventional biopsy forceps. We compared the diagnostic yield and safety of TBLB with cryoprobe sampling versus conventional forceps sampling. Methods This randomized clinical trial analysed data for 77 patients undergoing TBLB for evaluation of ILD; patients were assigned to either a conventional‐forceps group or a cryoprobe group. Two pathologists assessed the tissue samples and agreed on histopathologic diagnoses. We also compared the duration of procedures, complications and sample‐quality variables. Results The most frequent diagnosis observed in the cryoprobe group was non‐specific interstitial pneumonia. Histopathologic diagnoses were identified in more cases in the cryoprobe group (74.4%) than in the conventional‐forceps group (34.1%) (P 
ISSN:1323-7799
1440-1843
DOI:10.1111/resp.12322